热烈祝贺团队博士生高志雪、杨自立、徐文涛，以及罗明副研究员撰写的综述文章“Injectable nanorobots for precision cancer therapy: motion-enhanced drug delivery”被高影响力的国际权威期刊 Chemical Society Reviews（2025年IF: 39，JCR Q1期刊）接收！
癌症依然是全球重大健康挑战，亟需创新性策略来突破传统疗法的局限。尽管基于纳米颗粒的药物递送系统展现出潜力，但其临床转化仍受限于低靶向效率和不充分的组织渗透。相比之下，可注射纳米机器人能够依靠外部场或内源燃料实现自主运动，为精准药物递送提供了一种变革性技术。在简要讨论其推进机制以及设计与制备后，本文系统总结了用于精准癌症治疗的可注射纳米机器人在六个关键阶段中的动态表现：循环（Circulation）、靶向（Targeting）、渗透（Penetration）、内吞（Internalization）、释放（Release）和治疗（Treatment）（即CTPIRT过程）。与被动纳米颗粒相比，纳米机器人在增强的肿瘤富集、组织深层渗透以及细胞内化方面展现出显著优势。同时，它们能够通过刺激响应性药物释放及整合多种治疗策略，大幅增强治疗肿瘤效果。最后，本文深入探讨了规模化制备、生物安全性及临床转化中仍未解决的挑战，并提出跨学科策略以助力缩小实验室研究与临床应用之间的差距。总体而言，本综述凸显了可注射纳米机器人在精准药物递送中的应用潜力，为突破癌症治疗长期存在的障碍提供了新的路径。
原文摘要如下：Cancer remains a major global health challenge, demanding innovative strategies to overcome the limitations of conventional therapies. While nanoparticle-based drug delivery systems show potential, their clinical translation is hindered by low targeting efficiency and insufficient tissue penetration. Injectable nanorobots, capable of autonomous movement driven by external fields or endogenous fuels, offer a transformative technology to enhance drug delivery precision. Following the brief discussion of propulsion mechanisms, design and fabrication of injectable nanorobots, this review provides a comprehensive summary of injectable nanorobots designed for precision cancer therapy. It focuses on their dynamic performance across six critical stages: circulation, targeting, penetration, internalization, release, and treatment (CTPIRT process). Compared to passive nanoparticles, self-propelled nanorobots demonstrate superior tumor accumulation, deeper tissue penetration, and enhanced cellular internalization. Furthermore, they can substantially amplify therapeutic efficacy by enabling stimulus-responsive drug release and integrating diverse treatment strategies. Finally, this review delves into the unresolved challenges in scalable fabrication, biosafety, and clinical translation of injectable nanorobots. Interdisciplinary strategies are proposed to help bridge the gap between laboratory research and clinical translation. Together, this reviewhighlights injectable nanorobots as a paradigm shift in precision drug delivery, promising a path toward surmounting the long-standing barriers in cancer therapy.
