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林金卫、许蕾蕾研究员撰写的论文被 Advanced Materials接收

发布时间:2025-08-25

热烈祝贺我团队博士生林金卫、许蕾蕾研究员联合西班牙加泰罗尼亚生物工程研究所Prof. Samuel Sanchez撰写的综述文章Interactions between Active Matters and Endogenous FieldsWiley出版社旗舰期刊Advanced Materials (中科院一区TopIF=29.4)接收。

活性物质能够转换环境能量实现自主运动,展现出独特的非平衡特性。人工活性物质AAM,如纳米/微型马达,在精准药物递送和靶向治疗中具有巨大潜力,但其在体内的智能调控依然面临挑战。相比之下,自然活性物质NAM通过内源场信号,如化学梯度、电信号和力学刺激,实现迁移、取向与集体行为,这为人工系统的设计提供了宝贵启发。本文总结了肿瘤、伤口、炎症等典型生物环境中内源场的化学与物理特征,并系统梳理了NAMAAM对这些信号的感知、传递与响应机制。同时强调跨学科合作在推动活性物质智能化设计与应用中的关键作用,旨在为未来的生物医学应用奠定基础。

原文摘要如下:Active matter, natural or artificial, consumes environmental energy to sustain autonomous motion and exhibits distinctive non-equilibrium behaviors. Artificial active matter (AAM), including nano/micromotors, holds great promise for precision medicine by enhancing drug delivery and enabling targeted therapies. Yet, intelligent control of AAM in complex in vivo environments remains highly challenging due to their sensitivity to local conditions. In contrast, natural active matter (NAM) is guided by endogenous biological fields—chemical gradients, electrical signals, and mechanical cues—that direct migration, orientation, and collective transformations. These fields offer powerful strategies for regulating synthetic counterparts. Research in NAM-inspired AAM spans biology, chemistry, materials science, physics, and engineering, but disciplinary barriers often impede progress. This review aims to bridge such gapsby summarizing the chemical and physical features of endogenous fields in biological contexts such as tumors, wounds, and inflammation. It further examines how NAM and AAM sense, transmit, and respond to these cues, and how insights from natural systems can inspire artificial design. We also discuss challenges and future prospects. By fostering interdisciplinary collaboration, this review seeks to accelerate the development of intelligent active matter for biomedical applications.


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