胡俊仪、许蕾蕾等撰写的论文“Glucose-fueled Cationic Nanomotors for Promoting the Healing of Infected Diabetic Wounds”被期刊Journal of Colloid and Interface Science（2023年IF：9.4，中科院化学大类学科一区TOP期刊）接收！
糖尿病溃疡伤口的高血糖环境会促进细菌感染，严重恶化创面；而细菌的大量繁殖也会阻碍糖代谢，加速高血糖的产生。二者相互作用会导致糖尿病伤口的难愈合或不愈合。针对临床上抗生素联合降糖药治疗糖尿病感染创面存在脱靶效应、细菌耐药、血糖波动的问题，我们提出了一种以生理浓度葡萄糖为燃料的季铵化纳米马达，能够显著增强抗菌效果，加速糖尿病伤口愈合。该纳米马达表面带正电，由介孔碗状聚多巴胺纳米颗粒与季铵化聚合物刷接枝并偶联葡萄糖氧化酶(GOx)和过氧化氢酶(CAT)组成。由于糖尿病伤口微环境中的GOx-CAT级联反应，它们可以向高糖区（细菌增殖）和高H2O2区域（细菌代谢）进行趋化运动。这使得纳米马达能够定向迁移到富含细菌区域的同时降低血糖水平，并显著增强抗菌成分与细菌之间的静电相互作用。因此，纳米马达表面附着的阳离子分子表现出放大的接触杀伤效应，对大肠杆菌和金黄色葡萄球菌均表现出优异的抗菌和抗生物膜活性，其抗菌功效相比于的惰性粒子提高了近10倍。体内实验表明，纳米马达具有加速金黄色葡萄球菌感染的糖尿病伤口愈合和生物安全性。研究结果为糖尿病感染创面的临床治疗提供了新的思路。
原文摘要如下：Hyperglycemia-promoted bacterial infection will seriously exacerbate diabetic wounds, and its current clinical treatments are suffering from the adverse effects associated with off-target, bacterial resistance, and glycemic fluctuation. Herein, we present a kind of glucose-fueled cationic nanomotors capable of remarkably enhancing antibacterial efficacy, and thus expediting diabetic wound healing. The nanomotors have positively charged surfaces, and consist of mesoporous bowl-shaped polydopamine nanoparticles grafted with quaternized polymer brushes and coupled with glucose oxidase (GOx) and catalase (CAT). Stemming from the GOx-CAT cascade reaction in diabetic wound microenvironment, they can perform robust chemotactic motion towards both high glucose regions, where bacteria proliferation predominantly occurs, and elevated H2O2 levels, which bacterial metabolism produced. This enables the nanomotors to facilitate targeted migration towards bacteria-rich regions and simultaneous downregulation of glycemic levels, as well as to significantly enhance the electrostatic interaction between antibacterial components and bacteria. Consequently, the nanomotors exhibit amplified contact-killing effects of their attached cationic molecules, leading to an almost 10-fold enhancement in antibacterial efficacy compared to previous counterparts. The in vivo experiments approved that the nanomotors demonstrated the accelerated healing of infected diabetic wounds by S. aureus and biosafety. The results herein provide an insight into the clinical treatment of infected diabetic wounds.
