我组博士生杨满义、牟方志研究员与中部军区总医院李智主任医师等合作完成的研究论文“Swarming magnetic nanorobots bio-interfaced by heparinoid-polymer brushes for in vivo safe synergistic thrombolysis”被Science 子刊Science Advances（中科院1区Top期刊）接收！

    在该工作中，考虑到磁驱机器人集群的驱动力大、操控性强，能快速精确导航到血栓部位通过机械力或输送溶栓药物执行快速溶栓；但现有磁驱机器人集群在血液环境中面临着粒子个体间排斥力弱，易在血管中发生严重的聚集和生物粘附。这一局限性使其在临床溶栓应用中存在诸如脱靶毒性、毛细血管堵塞和外源性刺激带来二次血栓等重大风险和严重副作用。为此，我们采用原子转移自由基聚合在磁性粒子表面接枝长度适当的聚苯乙烯磺酸钠类肝素聚合物分子刷（HPBs），用它们构建磁驱纳米机器人集群。发现使用这种经HPBs修饰的纳米机器人在交变磁场B(t)控制下可实现安全、高效地体内靶向溶栓。由于HPBs能赋予纳米机器人个体粒子的高密度表面负电荷，纳米机器人集群在高离子强度血液环境中能表现出可逆组装、低溶血、抗生物粘附和自抗凝性能。它们可以在体外/体内血液环境中表现出“运动靶向”递药-机械破坏高效协同溶栓行为；而且在完成溶栓和去除B(t)后，它们在血液中还可自动分散成单个的颗粒，安全地参与血液循环并被免疫细胞吞噬，不会出现明显的器官损伤或炎症反应。这项研究为生物医用纳米机器人提供了一种合理的类肝素聚合物分子刷界面设计策略，并为生物医用纳米机器人的药物递送和靶向治疗提供了一个通用平台。
    原文摘要如下：Biocompatible swarming magnetic nanorobots are demonstrated that work in blood vessels for safe and efficient targeted thrombolytic therapy in vivo. This is achieved by using magnetic beads elaborately grafted with heparinoid-polymer brushes (HPBs) upon the application of an alternating magnetic field B(t). Due to the dense surface charges bestowed by HPBs, the swarming nanorobots demonstrate reversible agglomeration-free reconfigurations, low hemolysis, anti-bioadhesion, and self-anticoagulation in high-ionic-strength blood environments. They are confirmed in vitro and in vivo to perform synergistic thrombolysis efficiently by “motile-targeting” drug delivery and mechanical destruction. Moreover, upon the completion of thrombolysis and removal of B(t), the nanorobots disassemble into dispersed particles in blood, allowing them to safely participate in circulation and be phagocytized by immune cells without apparent organ damage or inflammatory lesion. This work provides a rational multifaceted heparinoid-polymer-brush bio-interfacing design strategy for biomedical nanorobots and a general motile platform to deliver drugs for targeted therapies.