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余政、牟方志等撰写的论文被InfoMat接收

发布时间:2023-06-06

    热烈祝贺我团队硕士生余政、牟方志老师等与哈尔滨工业大学李天龙教授合作撰写的研究论文“Swarming magnetic photonic-crystal microrobots with on-the-fly visual pH detection and self-regulated drug delivery”被材料学科著名学术期刊InfoMat(2021年IF:24.8,中科院1Top期刊)接收!

    磁驱微纳米机器人集群在生物医学应用方面有着巨大的前景,但其目前在感知和响应局部微环境的化学信号方面能力较差。在这里,我们发展了磁驱光子晶体微机器人(PC-bots)集群,它能够自发地进行可视化pH检测,并通过感知局部pH变化自我调节药物输送行为。

这种磁性PC-botspH响应性水凝胶微球与内部封装的一维周期性Fe3O4纳米颗粒组成。在可编程的外部磁场操控下,它们可以自组织形成大型集群,并且在闪烁着明亮结构色的同时以增强的运动速度主动寻找目标。当接近pH值异常的目标(如溃疡的浅表肿瘤病灶)时,PC-bots可以通过pH敏感的结构色实时观察到局部的pH值变化,并通过识别局部的pH值实现负载药物的自我调节释放。这项工作能促进用于“运动靶向”肿瘤诊断治疗的智能微纳米机器人的发展。

    原文摘要如下:Swarming magnetic micro/nanorobots hold great promise for biomedical applications, but at present suffer from inferior capabilities to perceive and respond to chemical signals in local microenvironments. Here we demonstrate swarming magnetic photonic-crystal microrobots (PC-bots) capable of spontaneously performing on-the-fly visual pH detection and self-regulated drug delivery by perceiving local pH changes. The magnetic PC-bots consist of pH-responsive hydrogel microspheres with encapsulated one-dimensional periodic assemblies of Fe3O4 nanoparticles. By programming external rotating magnetic fields, they can self-organize into large swarms with much-enhanced collective velocity to actively find targets while shining bright “blinking” structural colors. When approaching the target with abnormal pH conditions (e.g., an ulcerated superficial tumor lesion), the PC-bots can visualize local pH changes on the fly via pH-responsive structural colors, and realize self-regulated release of the loaded drugs by recognizing local pH. This work facilitates the development of intelligent micro/nanorobots for active “motile-targeting” tumor diagnosis and treatment.



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