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李罗霖、罗巍、牟方志等撰写的论文被Nano-Micro Letters接收

发布时间:2023-04-07

    热烈祝贺李罗霖、罗巍、牟方志等撰写的论文“Swarming Responsive Photonic Nanorobots for Motile-Targeting Microenvironmental Mapping and Mapping-Guided Photothermal Treatment”被上海交通大学主办的国内纳米材料学著名学术期刊Nano-Micro Letters(2021年IF:23.655,中科院一区Top期刊)接收,希望他们能再接再厉,为研究组的发展做出新的更大的贡献!

    微纳米机器人(MNRs)可以在许多难以触及的狭小生物环境中驱动和巡航,从而有望为生物医学研究和应用提供变革性技术。然而,目前的 MNRs 缺乏感知和报告未知微环境中物理化学信号变化的能力。在本工作中,我们开发了响应性光子纳米机器人集群(RPNR),它可以实时探测局部物理化学条件并进一步指导局部光热治疗。RPNR 由封装在响应性水凝胶壳中的周期性组装的磁性 Fe3O4纳米粒子的光子纳米链组成,并显示出多种集成功能,包括高效磁驱集群运动、明亮的刺激响应结构色和光热转换功能。因此,它们可以利用可控的集群运动在复杂的环境中主动巡航,然后通过响应性结构色集体映射出未知目标(如肿瘤病灶)的局部异常物理化学条件(如pH,温度或葡萄糖浓度),并进一步引导外部光照启动局部光热治疗。这项工作有利于促进智能运动纳米传感器和可用于癌症和炎症性疾病治疗的多功能纳米诊疗器的开发。

    原文摘要如下:Micro/nanorobots (MNRs) can propel and navigate in many hard-to-reach biological environments, and thus may bring revolutionary changes to biomedical research and applications. However, current MNRs lack the capability to collectively perceive and report physicochemical changes in unknown microenvironments. Here we propose to develop swarming responsive photonic nanorobots (RPNRs) that can map local physicochemical conditions on the fly and further guide localized photothermal treatment. The RPNRs consist of a photonic nanochain of periodically-assembled magnetic Fe3O4 nanoparticles encapsulated in a responsive hydrogel shell, and show multiple integrated functions, including energetic magnetically-driven swarming motions, bright stimuli-responsive structural colors, and photothermal conversion. Thus, they can actively navigate in complex environments utilizing their controllable swarming motions, then visualize unknown targets (e.g, tumor lesion) by collectively mapping out local abnormal physicochemical conditions (e.g, pH, temperature, or glucose concentration) via their responsive structural colors, and further guide external light irradiation to initiate localized photothermal treatment. This work facilitates the development of intelligent motile nanosensors and versatile multifunctional nanotheranostics for cancer and inflammatory diseases.


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