祝贺高天宇、林金卫和许蕾蕾等撰写的研究论文“Self-adaptive flask-like nanomotors based on Fe3O4 nanoparticles to a physiological pH”被期刊Nanomaterials（2021年影响因子IF：5.076）接收！生物体内精确调节的pH值能够作为本征标识来指示病变部位，可用于发展未来智能生物医学微系统。我们在本文中利用Fe3O4对pH依赖的类双酶活性，通过在炭质瓶状结构中装载Fe3O4纳米粒子发展了一种对特定生理pH值产生自适应运动特性的纳米马达。Fe3O4纳米粒子在酸性pH范围内的类过氧化物酶活性和在近中性和碱性pH范围内的类过氧化氢酶活性决定了运动体系中的产物种类为•OH、离子和O2。产物从烧瓶内部向外部的扩散导致流体运动为FCNMs的运动提供驱动力。由于产物浓度和种类的随pH的变化导致FCNMs的运动速度在生理pH范围（4.4-7.4）随着pH的增加先降低后增加。这种运动速度对pH的非线性响应，使马达展现出向微酸性pH值（6.8，通常对应于肿瘤微环境中的生理pH）趋化的特征并得到最大的运动速度。此外，Fe3O4的超顺磁特性还同时赋予了该马达磁性取向和易于分离的能力。这项工作能增加纳米马达用于肿瘤靶向治疗和下一代生物技术的可能性。

原文摘要如下：pH values in living bodies, which are precisely regulated and closely associated with diseased cells, can be acted as an efficient biologically intrinsic indicator for future intelligent biomedicine microsystems. In this work, we have developed the flask-like carbonaceous nanomotors (FCNMs)  carbonaceous nanomotors (FCNMs) via loading Fe3O4 nanoparticles (NPs) into a cavity, which exhibits a self-adaptive feature to a specific physiological pH by virtue of the pH-dependent dual enzyme-like activities of Fe3O4 NPs. Specifically, the peroxidase-like activity of Fe3O4 NPs in an acidic pH range and the catalase-like activity in a near neutral and alkaline pH range determine the products in the motion system (•OH, ions and O2), whose diffusions from the inner to the outside of the flask resulting in the fluid movement provides the driving force for the movement of the FCNMs. Correspondingly, the changes of the product concentrations and species in the physiological pH range (4.4-7.4) result in the velocity decrease firstly and then increase of the FCNMs with increasing pH. Thanks to the velocity non-linearly responsiveness, the FCNMs shows an intriguingly pH taxis towards 6.8 (generally corresponding to the physiological pH in tumor microenvironments) where a maximum velocity appears. Furthermore, the superparamagnetic feature of the Fe3O4 NPs simultaneously endows the FCNMs with the abilities to be magnetic-oriented and easily separated. This work could significantly increase the possibility of nanomotors for targeted therapy of tumor and next-generation biotechnological applications.