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蔡锦阳、罗巍和马会茹等撰写的研究论文被Advanced Science接收

发布时间:2022-01-25

    祝贺蔡锦阳、罗巍和马会茹等撰写的研究论文“Glucose-sensing photonic nanochain probes with color change in seconds”Wiley旗下著名的开放获取期刊Advanced Science2021年期刊影响因子IF: 16.806)接收!
    由于具有肉眼比色读数和无创糖尿病检测功能,葡萄糖传感光子晶体有望在连续血糖监测系统中取得重大进展,但其响应时间过长阻碍了其实际应用。在此研究中,我们首次证明了光子纳米链(PNC)探针能够在不需要外部电源的情况下,通过颜色变化在几秒钟内连续、可逆地检测葡萄糖浓度([glucose])的变化,比之前的探针快2~3个数量级。它们是由疏水单体3-丙烯酰胺基苯硼酸(AAPBA)和亲水单体N-2-羟乙基丙烯酰胺(HEAAm)在二甲亚砜(DMSO)-水二元微观异相溶剂中共聚形成20-30nm厚的水凝胶包覆固定一维等间距排列的磁性纳米粒子组成的。制备时,AAPBAHEAAm都优先溶解在聚集在Fe3O4@PVP胶体纳米粒子附近的少量游离DMSO相中,在外磁场下原位紫外光照聚合得到这种Fe3O4@PVP@poly(AAPBA-co-HEAAm) PNCs探针。当[glucose]0到20mM变化时,PNCs探针显色的光学波长变化范围可达130nm。PNCs探针能显著提升光子晶体葡萄糖传感器的微型化和实时监测水平;发展的聚合方法能为制备新型有机-无机纳米复合功能结构提供有效途径。

    
原文摘要如下:Glucose-sensing photonic crystals are promising for the significant advance of continuous glucose monitoring systems due to the naked-eye colorimetric readouts and non-invasive detection of diabetes, but the long response time hampers their practical applications. Herein, we have for the first time demonstrated probes of photonic nanochains (PNCs) that are capable of continuously and reversibly sensing glucose concentration ([glucose]) variation within seconds by color change without power consumption, much faster by 2~3 orders of magnitude than previous ones. They are comprised of one-dimensional equidistant arrays of magnetic nanoparticles enveloped by tens-of-nanometer-thick phenylboronic acid-functionalized hydrogels, and fabricated by developing selective concentration polymerization of monomers in binary microheterogeneous solvents of dimethyl sulfoxide (DMSO) and H2O. In this process, both 3-acrylamido phenylboronic acid (AAPBA) and N-2-hydroxyethyl acrylamide (HEAAm) are preferentially dissolved in the small volume of free DMSO concentrated in the vicinity of Fe3O4@PVP colloidal nanoparticles, yielding Fe3O4@PVP@poly(AAPBA-co-HEAAm) PNCs after UV irradiation under magnetic field. The PNCs in PBS buffer have a wavelength-shift range up to 130 nm when [glucose] changes from 0 to 20 mM. The results can facilitate real-time glucose monitoring, and provide an alternative to produce functional organic-inorganic nanostructures.



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