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罗明、冯有增等撰写的论文被Adv. Funct. Mater. 接收

发布时间:2017-12-20
       近日罗明助理研究员、冯有增硕士生等撰写的Invited Feature ArticleMicro-/Nanorobots at Work in Active Drug DeliveryAdv. Funct. Mater.(影响因子:12.124正式接收!在这篇论文中,我们讨论了现有微纳米马达的驱动机理和生理环境下的适应性和生物相容性,指出了用于主动给药的微纳米马达应该具备的条件。详细综述了微纳米马达在体外和体内主动给药的研究现状。指出了该领域研究目前存在的问题及未来的发展方向。
     原文的详细摘要如下:After the tremendous advances over the past two decades, micro-/nanorobots could effectively convert other forms of energy into propulsion and movement, as well as be navigated to targeted locations under physiological conditions and environments. They have been demonstrated to have the potential to load, transport and deliver therapeutic payloads directly to disease sites, thereby improving the therapeutic efficacy and reducing systemic side effects of highly toxic drugs. In this feature article, the various propulsion modalities of micro-/nanorobots ranging from chemical/biochemical reactions to external fields, and to motile microorganisms were summarized and commented in term of driving forces required by the automotive motion in biological media, biocompatibility as well as the corresponding advantages and limitations in term of biomedical applications. Then, the latest developments of in vitro and in vivo active drug delivery based on micro-/nanorobots were discussed in detail. The challenges and future prospects were also highlighted in the end. With ever booming research enthusiasm in this field and increasing multidisciplinary cooperation, micro-/nanorobots with intelligence and multifunctions will emerge in the near future, which would have a profound impact on the treatment of diseases.

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